DNA rearrangement activity during retinoic acid-induced neural differentiation of P19 mouse embryonal carcinoma cells.

@article{Kawabata2004DNARA,
  title={DNA rearrangement activity during retinoic acid-induced neural differentiation of P19 mouse embryonal carcinoma cells.},
  author={Masahiro Kawabata and Teruyuki Kawabata and Kazuhiko Saeki},
  journal={Acta medica Okayama},
  year={2004},
  volume={58 6},
  pages={
          263-70
        }
}
Because of the many superficial similarities between the immune system and the central nervous system, it has long been speculated that somatic DNA recombination is, like the immune system, involved in brain development and function. To examine whether or not the V(D)J recombination signals of the immune system work in an in vitro neural differentiation model, the P19 mouse embryonal carcinoma cell line was transfected with a reporter gene that is designed, when rearranged, to express bacterial… CONTINUE READING

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