DNA quality control by conformational readout on the undamaged strand of the double helix.

@article{Buterin2005DNAQC,
  title={DNA quality control by conformational readout on the undamaged strand of the double helix.},
  author={Tonko Buterin and Christoph Meyer and Bernd Giese and Hanspeter Naegeli},
  journal={Chemistry & biology},
  year={2005},
  volume={12 8},
  pages={913-22}
}
Synthetic DNA probes were incubated in human cell extracts to dissect the early step of bulky lesion recognition in the nucleotide excision repair pathway. Excision was induced upon combination of the target adduct with either a two-sided bulge, involving both the damaged sequence and its undamaged partner strand, or a one-sided bulge, affecting exclusively the undamaged complementary sequence. Surprisingly, the same adduct became refractory to repair when only the modified strand was bulged… CONTINUE READING

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