Corpus ID: 27465906

DNA-protein, DNA interstrand cross-links induced by camphoramine chloroacetic platinum in vitro.

@article{Wang1989DNAproteinDI,
  title={DNA-protein, DNA interstrand cross-links induced by camphoramine chloroacetic platinum in vitro.},
  author={L. Wang and H. Zeng},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1989},
  volume={10 3},
  pages={
          261-5
        }
}
  • L. Wang, H. Zeng
  • Published 1989
  • Chemistry, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
Effects of camphoramine chloroacetic platinum (CCP) on DNA migration and transcription, DNA-protein and DNA interstrand cross-links induced by CCP were investigated by using agarose gel electrophoresis, alkaline elution and enzymatic techniques, respectively. Chromosome break down and migration alteration of DNa modified by CCP were observed. Plasmid pAR 436 DNA transcription was also blocked when the DNA was treated with CCP. The cross-links took place 8 h after HeLa cells were exposed to CCP… Expand