DNA protection by histone-like protein HU from the hyperthermophilic eubacterium Thermotoga maritima

@inproceedings{Mukherjee2008DNAPB,
  title={DNA protection by histone-like protein HU from the hyperthermophilic eubacterium Thermotoga maritima},
  author={Anirban Mukherjee and Abimbola O. Sokunbi and Anne Grove},
  booktitle={Nucleic acids research},
  year={2008}
}
In mesophilic prokaryotes, the DNA-binding protein HU participates in nucleoid organization as well as in regulation of DNA-dependent processes. Little is known about nucleoid organization in thermophilic eubacteria. We show here that HU from the hyperthermophilic eubacterium Thermotoga maritima HU bends DNA and constrains negative DNA supercoils in the presence of topoisomerase I. However, while binding to a single site occludes approximately 35 bp, association of T. maritima HU with DNA of… CONTINUE READING
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