DNA probe for strain typing of Cryptococcus neoformans.

  title={DNA probe for strain typing of Cryptococcus neoformans.},
  author={Ashok Varma and Kyung J. Kwon-Chung},
  journal={Journal of clinical microbiology},
  volume={30 11},
A 7-kb linear plasmid, harbored by a URA5 transformant, hybridized to all the chromosomes of Cryptococcus neoformans separated by contour-clamped homogeneous electric field electrophoresis. Its linear maintenance was determined to have been facilitated by the presence of telomere-like sequences at its free ends. Hybridization of this plasmid to AccI-digested genomic DNAs of 26 C. neoformans strains generated 21 unique DNA fingerprints. The DNA fingerprints of isolates within the same serotype… CONTINUE READING


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