DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication.

@article{Boyer2005DNAPL,
  title={DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication.},
  author={Jean D. Boyer and Tara M. Robinson and Paulo Cesar Maciag and Xiaohui Peng and Ross S Johnson and George M Pavlakis and Mark G. Lewis and Anding Shen and Robert F. Siliciano and Charles R Brown and David B. Weiner and Yvonne Paterson},
  journal={Virology},
  year={2005},
  volume={333 1},
  pages={88-101}
}
DNA vaccines and recombinant Listeria monocytogenes that express and secrete SIV Gag and Env antigens were combined in a nonhuman primate prime-boost immunogenicity study followed by a challenge with SIV239. We report that recombinant DNA vaccine delivered intramuscularly, and recombinant L. monocytogenes delivered orally each individually have the ability to induce CD8+ and CD4+ T cell immune responses in a nonhuman primate. Four rhesus monkeys were immunized at weeks 0, 4, 8, and 12 with the… CONTINUE READING