DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice

@article{Davtyan2010DNAPB,
  title={DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice},
  author={Hasmik Davtyan and Mikayel Mkrtichyan and N. R. Movsesyan and Sergey Khudyakov and Grigor Mamikonyan and David Hastings Cribbs and Michael G. Agadjanyan and Anahit Ghochikyan},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={261-271}
}
Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-β (Aβ42) and the foreign T-cell epitope, Pan DR epitope (PADRE), generated strong anti-Aβ immune responses in wild-type and amyloid precursor protein transgenic animals. Although DNA vaccines have several advantages over peptide–protein vaccines, they induce lower immune responses in large animals and humans compared with those in mice. The focus of this study was to further enhance anti-Aβ11… CONTINUE READING
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