DNA polymorphisms in the pepA and PPE18 genes among clinical strains of Mycobacterium tuberculosis: implications for vaccine efficacy.

@article{Hebert2007DNAPI,
  title={DNA polymorphisms in the pepA and PPE18 genes among clinical strains of Mycobacterium tuberculosis: implications for vaccine efficacy.},
  author={Andrea M Hebert and Sarah Talarico and Dong Yang and Riza Durmaz and Carl F. Marrs and Lixin Zhang and Betsy Foxman and Zhenhua Yang},
  journal={Infection and immunity},
  year={2007},
  volume={75 12},
  pages={5798-805}
}
Tuberculosis continues to be a leading cause of death worldwide. Development of an effective vaccine against Mycobacterium tuberculosis is necessary to reduce the global burden of this disease. Mtb72F, consisting of the protein products of the pepA and PPE18 genes, is the first subunit tuberculosis vaccine to undergo phase I clinical trials. To obtain insight into the ability of Mtb72F to induce an immune response capable of recognizing different strains of M. tuberculosis, we investigated the… CONTINUE READING

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