DNA polymerases and cancer

@article{Lange2011DNAPA,
  title={DNA polymerases and cancer},
  author={Sabine Sue Lloyd Lange and Kei‐ichi Takata and Richard D Wood},
  journal={Nature Reviews Cancer},
  year={2011},
  volume={11},
  pages={96-110}
}
There are 15 different DNA polymerases encoded in mammalian genomes, which are specialized for replication, repair or the tolerance of DNA damage. New evidence is emerging for lesion-specific and tissue-specific functions of DNA polymerases. Many point mutations that occur in cancer cells arise from the error-generating activities of DNA polymerases. However, the ability of some of these enzymes to bypass DNA damage may actually defend against chromosome instability in cells, and at least one… CONTINUE READING
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