DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.

@article{Braithwaite2005DNAPL,
  title={DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.},
  author={Elena K. Braithwaite and Padmini Kedar and Li Lan and Yaroslava Y. Polosina and Kenjiro Asagoshi and Vladimir Poltoratsky and Julie K. Horton and Holly Miller and George W. Teebor and Akira Yasui and Samuel H. Wilson},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 36},
  pages={31641-7}
}
DNA polymerase lambda (pol lambda) is a member of the X family of DNA polymerases that has been implicated in both base excision repair and non-homologous end joining through in vitro studies. However, to date, no phenotype has been associated with cells deficient in this DNA polymerase. Here we show that pol lambda null mouse fibroblasts are hypersensitive to oxidative DNA damaging agents, suggesting a role of pol lambda in protection of cells against the cytotoxic effects of oxidized DNA… CONTINUE READING