DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.

@article{Albertson2009DNAPE,
  title={DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.},
  author={Tina M. Albertson and Masanori Ogawa and James M Bugni and Laura E. Hays and Yang Chen and Yanping Wang and Piper M Treuting and John A. Heddle and Robert E Goldsby and Bradley D. Preston},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 40},
  pages={17101-4}
}
Organisms require faithful DNA replication to avoid deleterious mutations. In yeast, replicative leading- and lagging-strand DNA polymerases (Pols epsilon and delta, respectively) have intrinsic proofreading exonucleases that cooperate with each other and mismatch repair to limit spontaneous mutation to less than 1 per genome per cell division. The relationship of these pathways in mammals and their functions in vivo are unknown. Here we show that mouse Pol epsilon and delta proofreading… CONTINUE READING
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