DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA.

@article{Langston2008DNAPD,
  title={DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA.},
  author={Lance D Langston and Mike O'Donnell},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 43},
  pages={29522-31}
}
In most cells, 100-1000 Okazaki fragments are produced for each replicative DNA polymerase present in the cell. For fast-growing cells, this necessitates rapid recycling of DNA polymerase on the lagging strand. Bacteria produce long Okazaki fragments (1-2 kb) and utilize a highly processive DNA polymerase III (pol III), which is held to DNA by a circular sliding clamp. In contrast, Okazaki fragments in eukaryotes are quite short, 100-250 bp, and thus the eukaryotic lagging strand polymerase… CONTINUE READING

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Chromosomal Replication in Escherichia coli: Mechanisms of Lagging Strand DNA Synthesis Ph.D. Thesis, Cornell Medical College, New York pol -PCNA Collision Release Mechanism

  • F. P. Leu
  • OCTOBER 24,
  • 2002

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