DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.

@article{Parsons2005DNAPB,
  title={DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.},
  author={Jason L. Parsons and Irina I. Dianova and Sarah L. Allinson and Grigory L Dianov},
  journal={Biochemistry},
  year={2005},
  volume={44 31},
  pages={10613-9}
}
Base excision repair is a major pathway for the removal of simple lesions in DNA including base damage and base loss (abasic site). Base excision repair requires the coordinated action of several repair and ancillary proteins, the impairment of which can lead to genetic instability. Using a protein-DNA cross-linking assay during repair in human whole cell extracts, we monitored proteins involved in the initial steps of repair of a substrate containing a site-specific abasic site to address the… CONTINUE READING
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