DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

To determine whether DNA polymerase η plays a role in the hypermutation of immunoglobulin variable genes, we examined the frequency and pattern of substitutions in variable VH6 genes from the peripheral blood lymphocytes of three patients with xeroderma pigmentosum variant disease, whose polymerase η had genetic defects. The frequency of mutation was normal… CONTINUE READING