DNA-polycation complexes: effect of polycation structure on physico-chemical and biological properties.

@article{Slita2007DNApolycationCE,
  title={DNA-polycation complexes: effect of polycation structure on physico-chemical and biological properties.},
  author={Alexandr Slita and N. A. Kasyanenko and Olga V Nazarova and Irina I Gavrilova and E. M. Eropkina and Alexey K. Sirotkin and Tatiana D. Smirnova and Oleg I. Kiselev and Evgeny F. Panarin},
  journal={Journal of biotechnology},
  year={2007},
  volume={127 4},
  pages={679-93}
}
The purpose of the study was to investigate the influence of cationic polymer structure on the formation of DNA-polycation complexes and their transfection activity. Primary, tertiary, and quaternary polyamines with molecular masses ranging from 8000 to 200,000 were investigated. DNA-cationic polymer interaction was characterized by low gradient viscometry, dynamic light scattering, circular dichroism, UV spectrometry, flow birefringence, DNA electrophoresis, and electron microscopy… CONTINUE READING

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DNA - cationic polymer interaction was characterized by low gradient viscometry , dynamic light scattering , circular dichroism , UV spectrometry , flow birefringence , DNA electrophoresis , and electron microscopy .
Complex formation was found to be dependent on the structure and molecular weight of the polymer and the ionic strength of the solution .
Complex formation was found to be dependent on the structure and molecular weight of the polymer and the ionic strength of the solution .
DNA - cationic polymer interaction was characterized by low gradient viscometry , dynamic light scattering , circular dichroism , UV spectrometry , flow birefringence , DNA electrophoresis , and electron microscopy .
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