DNA ploidy and S-phase in recurrent astrocytomas: a retrospective study by flow cytometry of deparaffinized specimens

@article{Vavruch1996DNAPA,
  title={DNA ploidy and S-phase in recurrent astrocytomas: a retrospective study by flow cytometry of deparaffinized specimens},
  author={Ludek Vavruch and B O Nordenskj{\"o}ld and John M. Carstensen and Sverker Enestr{\"o}m},
  journal={Journal of Neuro-Oncology},
  year={1996},
  volume={30},
  pages={37-45}
}
Twenty-two patients with recurrent astrocytic tumors were treated surgically two or even three times. At the time of the first surgery 6 tumors were fibrillary astrocytomas (grade II), 9 anaplastic astrocytomas (grade III) and 7 glioblastomas (grade IV). Histopathological specimens from second surgery demonstrated in 12 cases signs of higher grades of malignancy. Flow cytometry (FCM) did not reveal any significant changes of S-phase fraction (p = 0.55). This study supports the theory that… CONTINUE READING

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