DNA plasticity and damage in amyotrophic lateral sclerosis

  title={DNA plasticity and damage in amyotrophic lateral sclerosis},
  author={Diane Penndorf and Otto W. Witte and Alexandra Kretz},
  booktitle={Neural regeneration research},
The pathophysiology of amyotrophic lateral sclerosis (ALS) is particularly challenging due to the heterogeneity of its clinical presentation and the diversity of cellular, molecular and genetic peculiarities involved. Molecular insights unveiled several novel genetic factors to be inherent in both familial and sporadic disease entities, whose characterizations in terms of phenotype prediction, pathophysiological impact and putative prognostic value are a topic of current researches. However… CONTINUE READING