DNA photolyases: physical properties, action mechanism, and roles in dark repair.

@article{Sancar1990DNAPP,
  title={DNA photolyases: physical properties, action mechanism, and roles in dark repair.},
  author={Gwendolyn B. Sancar},
  journal={Mutation research},
  year={1990},
  volume={236 2-3},
  pages={147-60}
}
DNA photolyases catalyze the light-dependent repair of cis,syn-cyclobutane dipyrimidines (pyrimidine dimers). Although the phenomenon of enzymatic photoreactivation was first described 40 years ago and photolyases were the first enzymes shown unequivocally to effect DNA repair, it has only been in the last 8 years that sufficient quantities of the enzymes have been purified to permit detailed studies of their physical properties, identification of their intrinsic chromophores, and elucidation… CONTINUE READING

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