DNA packaging induced by micellar aggregates: a novel in vitro DNA condensation system.

@article{Ghirlando1992DNAPI,
  title={DNA packaging induced by micellar aggregates: a novel in vitro DNA condensation system.},
  author={Rodolfo Ghirlando and E. J. Wachtel and Talmon Arad and Abraham Minsky},
  journal={Biochemistry},
  year={1992},
  volume={31 31},
  pages={7110-9}
}
Evidence for a conceptually novel DNA packaging process is presented. X-ray scattering, electron microscopy, and circular dichroism measurements indicate that in the presence of positively charged micellar aggregates and flexible anionic polymers, such as negatively charged polypeptides or single-stranded RNA species, a complex is formed in which DNA molecules are partially embedded within a micellar scaffold and partially condensed into highly packed chiral structures. Based on studies of… CONTINUE READING

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