DNA origami nanopores for controlling DNA translocation.

@article{HernndezAinsa2013DNAON,
  title={DNA origami nanopores for controlling DNA translocation.},
  author={Silvia Hern{\'a}ndez-Ainsa and Nicholas A. W. Bell and Vivek V. Thacker and Kerstin G{\"o}pfrich and Karolis Misiunas and Maria Eugenia Fuentes-Perez and Fernando Moreno-Herrero and Ulrich F Keyser},
  journal={ACS nano},
  year={2013},
  volume={7 7},
  pages={
          6024-30
        }
}
We combine DNA origami structures with glass nanocapillaries to reversibly form hybrid DNA origami nanopores. Trapping of the DNA origami onto the nanocapillary is proven by imaging fluorescently labeled DNA origami structures and simultaneous ionic current measurements of the trapping events. We then show two applications highlighting the versatility of these DNA origami nanopores. First, by tuning the pore size we can control the folding of dsDNA molecules ("physical control"). Second, we… CONTINUE READING
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