DNA nanotubes as intracellular delivery vehicles in vivo.

  title={DNA nanotubes as intracellular delivery vehicles in vivo.},
  author={Sabine Sellner and Samet Kocabey and Katharina Nekolla and Fritz Krombach and Tim Liedl and Markus Rehberg},
DNA-based nanoconstructs possess great potential for biomedical applications. However, the in vivo behavior of such constructs at the microscopic tissue/cell level as well as their inflammatory potential is largely unknown. Unmethylated CpG sequences of DNA are recognized by Toll-like receptor 9 (TLR9), and thus initiate an innate immune response. In this study, we investigated the use of DNA-based nanotubes as carrier systems for CpG delivery and their effect on immune cells in vivo and in… CONTINUE READING