DNA motifs associated with aberrant CpG island methylation.

  title={DNA motifs associated with aberrant CpG island methylation.},
  author={Frank Alex Feltus and Eva K. Lee and Joseph F. Costello and Christoph Plass and P M Vertino},
  volume={87 5},
Epigenetic silencing involving the aberrant methylation of promoter region CpG islands is widely recognized as a tumor suppressor silencing mechanism in cancer. However, the molecular pathways underlying aberrant DNA methylation remain elusive. Recently we showed that, on a genome-wide level, CpG island loci differ in their intrinsic susceptibility to aberrant methylation and that this susceptibility can be predicted based on underlying sequence context. These data suggest that there are… CONTINUE READING
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