DNA modification by oxovanadium(IV) complexes of salen derivatives

  title={DNA modification by oxovanadium(IV) complexes of salen derivatives},
  author={Geraldine Verquin and Ga{\"e}lle Fontaine and Marc Bria and Elena Zhilinskaya and Edmond Abi-Aad and Antoine Abouka{\"i}s and Brigitte Baldeyrou and Christian Bailly and Jean-Luc T Bernier},
  journal={JBIC Journal of Biological Inorganic Chemistry},
Oxovanadium(IV) complexes of hydroxysalen derivatives have been prepared and tested as DNA reactive agents. The nuclease activity has been investigated under oxidative or reducing conditions, on the basis of the various oxidation states of vanadium: VIII, VIV and VV. In the absence of an activating agent, none of the compounds tested was able to induce… CONTINUE READING