DNA mismatch repair: Dr. Jekyll and Mr. Hyde?


In this issue, Peña-Diaz et al. (2012) describe a pathway for somatic mutation in nonlymphoid cells termed noncanonical DNA mismatch repair, whereby the error-prone translesion polymerase Pol-η substitutes for high-fidelity replicative polymerases to resynthesize excised regions opposite DNA damage. 
DOI: 10.1016/j.molcel.2012.08.020

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