DNA minor groove binders as potential antitumor and antimicrobial agents.

  title={DNA minor groove binders as potential antitumor and antimicrobial agents.},
  author={Pier Giovanni Baraldi and Andrea Bovero and Francesca Fruttarolo and Delia Preti and Mojgan Aghazadeh Tabrizi and Maria Giovanna Pavani and Romeo Romagnoli},
  journal={Medicinal research reviews},
  volume={24 4},
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form noncovalent complexes with DNA (e.g., distamycin A, Hoechst 33258, and pentamidine) while others DNA-binding compounds (such as CC-1065) cause cleavages in the DNA backbone. In this article, we have reviewed the minor groove binders currently in preclinical evaluation in the last years. Diarylamidines such as DAPI, berenil, and pentamidine; bis-benzimidazoles such as Hoechst… CONTINUE READING


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