DNA microenvironments and the molecular clock

  title={DNA microenvironments and the molecular clock},
  author={Cecilia Saccone and Graziano Pesole and Giuliano Preparata},
  journal={Journal of Molecular Evolution},
A few years ago we presented a stationary Markov model of gene evolution according to which only homologous genes from not too divergent species obeying the condition of being stationary may behave as reliable molecular clocks. A compartmentalized model of the nuclear genome in which the genes are distributed in compartments, the isochores, defined by their G+C content has been proposed recently. We have found that only homologous gene pairs that are stationary, and belong to the same isochore… CONTINUE READING

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