DNA microarrays with PAMAM dendritic linker systems.

  title={DNA microarrays with PAMAM dendritic linker systems.},
  author={R{\"u}diger Benters and Christof M Niemeyer and Denja Drutschmann and Dietmar Blohm and Dieter W{\"o}hrle},
  journal={Nucleic acids research},
  volume={30 2},
The DNA microarray-based analysis of single nucleotide polymorphisms (SNPs) is important for the correlation of genetic variations and individual phenotypes, and for locating disease-causing genes. To facilitate the development of surfaces suitable for immobilization of oligonucleotides, we report here a novel method for the surface immobilization of DNA using pre-fabricated polyamidoamine (PAMAM) starburst dendrimers as mediator moieties. Dendrimers containing 64 primary amino groups in their… CONTINUE READING


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