DNA microarrays on nanoscale-controlled surface

@article{Hong2005DNAMO,
  title={DNA microarrays on nanoscale-controlled surface},
  author={Bong Jin Hong and Vijaya Sunkara and Joon Won Park},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={e106 - e106}
}
We have developed new surface to ensure a proper spacing between immobilized biomolecules. While DNA microarray on this surface provided each probe DNA with ample space for hybridization with incoming target DNAs, the microarray showed enhanced discrimination efficiency for various types of single nucleotide polymorphism. The high discrimination efficiency holds for all tested cases (100:<1 for internal mismatched cases; 100:<28 for terminal mismatched ones). In addition, by investigating… CONTINUE READING

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