DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1

  title={DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1},
  author={Karuppiah Kannan and Naftali Kaminski and Gideon Rechavi and Jasmine Jakob-Hirsch and Ninette Amariglio and David Givol},
The transcription regulation activity of p53 controls cellular response to a variety of stress conditions, leading to growth arrest and apoptosis. Despite major progress in the understanding of the global effects of p53 on cellular function the pathways by which p53 activates apoptosis are not well defined. To study genes activated in the p53 induced apoptotic process, we used a mouse myeloid leukemic cell line (LTR6) expressing the temperature-sensitive p53 (val135) that undergoes apoptosis… CONTINUE READING


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