DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys.

@article{Chang2016DNAMI,
  title={DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys.},
  author={Yu-ting Chang and Ching-Chin Yang and Szu-Yu Pan and Yu-Hsiang Chou and Fan-Chi Chang and C Lai and Ming-Hsuan Tsai and Huan-Lun Hsu and Ching-hung Lin and Wen-Chih Chiang and M S Wu and T. -S. Chu and Yung-Ming Chen and Shuei-Liong Lin},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 2},
  pages={721-31}
}
Renal erythropoietin-producing cells (REPCs) remain in the kidneys of patients with chronic kidney disease, but these cells do not produce sufficient erythropoietin in response to hypoxic stimuli. Treatment with HIF stabilizers rescues erythropoietin production in these cells, but the mechanisms underlying the decreased response of REPCs in fibrotic kidneys… CONTINUE READING

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