DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen.

@article{Yamagata2009DNAME,
  title={DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen.},
  author={Yoshiaki Yamagata and Hiromi Asada and Isao Tamura and Lifa Merry Lee and Ryo Maekawa and Ken Taniguchi and Toshiaki Taketani and Aki Matsuoka and Hiroshi Tamura and Norihiro Sugino},
  journal={Human reproduction},
  year={2009},
  volume={24 5},
  pages={
          1126-32
        }
}
BACKGROUND Epigenetic regulation may be involved in modulation of gene expression during the normal cyclic changes of the human endometrium. We investigated expression of DNA methyltransferases (DNMTs) in endometrium during the menstrual cycle and the influence of sex steroid hormones on DNMT in endometrial stromal cells (ESC) in culture. METHODS Expression of DNMT1, DNMT3a and DNMT3b was assessed by immunohistochemistry and real-time RT-PCR in endometrial tissue (n = 42 women). ESC (n = 3… CONTINUE READING
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