DNA methyltransferase Dnmt1 associates with histone deacetylase activity

@article{Fuks2000DNAMD,
  title={DNA methyltransferase Dnmt1 associates with histone deacetylase activity},
  author={François Fuks and Wendy A. Burgers and Alexander Brehm and Luke Hughes-Davies and Tony Kouzarides},
  journal={Nature Genetics},
  year={2000},
  volume={24},
  pages={88-91}
}
The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and has a role in gene silencing. DNA methylation represses genes partly by recruitment of the methyl-CpG-binding protein MeCP2, which in turn recruits a histone deacetylase activity. Here we show that Dnmt1 is itself associated with histone deacetylase activity in vivo. Consistent with this association, we find that one of the known histone deacetylases, HDAC1, has the ability to bind Dnmt1 and can purify… Expand
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