DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

@article{Nishikawa2015DNAM3,
  title={DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway},
  author={Keizo Nishikawa and Yoriko Iwamoto and Yasuhiro Kobayashi and Fumiki Katsuoka and Shin-ichi Kawaguchi and Tadayuki Tsujita and Takashi Nakamura and Shigeaki Kato and Masayuki Yamamoto and Hiroshi Takayanagi and Masaru Ishii},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={281-287}
}
Metabolic reprogramming occurs in response to the cellular environment to mediate differentiation, but the fundamental mechanisms linking metabolic processes to differentiation programs remain to be elucidated. During osteoclast differentiation, a shift toward more oxidative metabolic processes occurs. In this study we identified the de novo DNA methyltransferase 3a (Dnmt3a) as a transcription factor that couples these metabolic changes to osteoclast differentiation. We also found that receptor… CONTINUE READING
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