DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation.

@article{Cirio2008DNAM1,
  title={DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation.},
  author={Mar{\'i}a Cecilia Cirio and Jos{\'e}e Martel and Mellissa R W Mann and Marc Toppings and Marisa S Bartolomei and Jacquetta M. Trasler and J. Richard Chaillet},
  journal={Developmental biology},
  year={2008},
  volume={324 1},
  pages={139-50}
}
Most mouse embryos developing in the absence of the oocyte-derived DNA methyltransferase 1o (DNMT1o-deficient embryos) have significant delays in development and a wide range of anatomical abnormalities. To understand the timing and molecular basis of such variation, we studied pre- and post-implantation DNA methylation as a gauge of epigenetic variation among these embryos. DNMT1o-deficient embryos showed extensive differences in the levels of methylation in differentially methylated domains… CONTINUE READING
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139–150 intracellular localization during oogenesis and preimplantation development

  • M. C. Cirio
  • Developmental Biology
  • 2008

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