DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.

@article{Milutinovic2004DNAM1,
  title={DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.},
  author={Snezana Milutinovic and Shelley E. Brown and Qianli Zhuang and Moshe Szyf},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 27},
  pages={27915-27}
}
DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is responsible for maintaining the DNA methylation pattern during cell division. A long list of data supports a role for DNMT1 in cellular transformation and inhibitors of DNMT1 were shown to have antitumorigenic effects. It was long believed that DNMT1 promoted tumorigenesis by maintaining the hypermethylated and silenced state of tumor suppressor genes. We have previously shown that DNMT1 knock down by… CONTINUE READING
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