DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish

@inproceedings{Liu2015DNAM1,
  title={DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish},
  author={Xiaohui Liu and Xiaoe Jia and Hao Yuan and Ke Ma and Y Chen and Yi Jin and Min Deng and Weijun Pan and Sai-juan Chen and Zhu Chen and Hugues de Th{\'e} and Leonard I. Zon and Yi Zhou and Jun Zhou and Jun Zhu},
  booktitle={Journal of hematology & oncology},
  year={2015}
}
BACKGROUND DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development and diverse biological processes, including maintenance of hematopoietic stem and progenitor cells (HSPCs). However, the precise molecular mechanism of how Dnmt1 is involved in HSPC maintenance remains unexplored. METHODS An N-ethyl-N-nitrosourea (ENU)-based genetic… CONTINUE READING
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