DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.

@article{Sun2008DNAM1,
  title={DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.},
  author={Lunching Sun and Lei Vincent Huang and Phuongmai Nguyen and Kheem S. Bisht and Gil Bar-Sela and Allen S Ho and C. Matthew Bradbury and Wenqiang Yu and Hengmi Cui and S Justin Lee and Jane B. Trepel and Andrew P. Feinberg and David R. Gius},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2726-35}
}
In a previous genomic analysis, using somatic methyltransferase (DNMT) knockout cells, we showed that hypomethylation decreased the expression of as many genes as were observed to increase, suggesting a previously unknown mechanism for epigenetic regulation. To address this idea, the expression of the BAG family genes was used as a model. These genes were used because their expression was decreased in DNMT1(-/-), DNMT3B(-/-), and double knockout cells and increased in DNMT1-overexpressing and… CONTINUE READING
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Establishment and maintenance of DNA methylation patterns in mammals.

Current topics in microbiology and immunology • 2006
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