DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

@inproceedings{Sagvekar2019DNAMP,
  title={DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome},
  author={Pooja Sagvekar and Pankaj Kumar and Vijay S. Mangoli and Sadhana Desai and Srabani Mukherjee},
  booktitle={Clinical epigenetics},
  year={2019}
}
BACKGROUND Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly affect their reproductive health. Addressing the putative epigenetic anomalies that tightly regulate these events is of foremost importance in this disorder. We therefore aimed to carry out DNA methylome profiling of cumulus granulosa cells and assess the methylation and transcript expression profiles of a few… CONTINUE READING
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