DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.

@article{Liu2011DNAMS,
  title={DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.},
  author={Hongyan Liu and Huijia Dong and Keith M Robertson and Chen Liu},
  journal={The American journal of pathology},
  year={2011},
  volume={178 2},
  pages={652-61}
}
Carbamoyl phosphate synthetase 1 (CPS1) is a liver-specific, intramitochondrial, rate-limiting enzyme in the urea cycle. A previous study showed that CPS1 is the antigen for hepatocyte paraffin 1 antibody, a commonly used antibody in surgical pathology practice; and CPS1 expression appears to be down-regulated in liver cancer tissue and cell lines. The aim of this study is to understand how the CPS1 gene is regulated in liver carcinogenesis. In this report, we show that human hepatocellular… CONTINUE READING
28 Extracted Citations
29 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 28 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 29 references

Tannapfe A: DNA methylation in hepatocellular carcinoma

  • I Tischoff
  • World J Gastroenterol
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…