DNA methylation signatures of mood stabilizers and antipsychotics in bipolar disorder.

@article{Houtepen2016DNAMS,
  title={DNA methylation signatures of mood stabilizers and antipsychotics in bipolar disorder.},
  author={Lotte C. Houtepen and Annet H van Bergen and Christiaan H. Vinkers and Marco P. M. Boks},
  journal={Epigenomics},
  year={2016},
  volume={8 2},
  pages={
          197-208
        }
}
AIM In view of the potential effects of psychiatric drugs on DNA methylation, we investigated whether medication use in bipolar disorder is associated with DNA methylation signatures. EXPERIMENTAL PROCEDURES Blood-based DNA methylation patterns of six frequently used psychotropic drugs (lithium, quetiapine, olanzapine, lamotrigine, carbamazepine, and valproic acid) were examined in 172 bipolar disorder patients. After adjustment for cell type composition, we investigated gene networks… 
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DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder
TLDR
Data support the hypothesis that DNA methylation levels at specific CpG sites have been documented for all classes of treatments (antipsychotics, mood stabilizers, and antidepressants) and data support this hypothesis for antipsychotic, Mood stabilizers and antidepressants.
The role of DNA methylation in the pathophysiology and treatment of bipolar disorder
Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review
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The state of the pharmacoepigenetic literature on antipsychotic use is still in its early stages and uniform reporting of methylation site information is needed, so future work should concentrate on using prospective sampling with appropriate control groups and begin to replicate many of the novel associations that have been reported.
Epigenetics in bipolar disorder: a critical review of the literature.
TLDR
Epigenetic is a growing and promising field in BD that may shed light on its pathophysiology or be useful as biomarkers of response to mood-stabilizer.
Dissecting the Epigenetic Changes Induced by Non-Antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review
TLDR
An advanced understanding of the specific epigenetic changes induced by classic mood stabilizers in patients with major psychiatric disorders will facilitate personalized interventions.
Pharmacoepigenetics of Bipolar Disorder
  • G. Fries
  • Psychology, Biology
    Pharmacoepigenetics
  • 2019
Genetic and Epigenetic Markers of Lithium Response
TLDR
The most replicated findings among candidate gene studies, results from genome-wide association studies (GWAS) as well as post-GWAS approaches supporting an association between high genetic load for schizophrenia, major depressive disorder or attention deficit/hyperactivity disorder and poor lithium response are described.
The Methylome of Bipolar Disorder: Evidence from Human and Animal Studies
TLDR
Recent genome-wide findings of alterations in DNA methylation in brain and blood of patients with bipolar disorder and in relevant animal models are reviewed to review the potential clinical implications, limitations, and future directions of the field of bipolar disorder epigenetics.
Non-genetic transgenerational transmission of bipolar disorder: targeting DNA methyltransferases
TLDR
Bipolar disorder has been shown to present a strong1 and complex2 genetic component, even though common variants found in genome-wide association studies still account for only a small fraction of BD heritability, and non-genetic mechanisms have a role in its risk and onset.
Understanding the molecular mechanisms underlying mood stabilizer treatments in bipolar disorder: Potential involvement of epigenetics
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