DNA methylation signatures link prenatal famine exposure to growth and metabolism

@inproceedings{Tobi2014DNAMS,
  title={DNA methylation signatures link prenatal famine exposure to growth and metabolism},
  author={Elmar W. Tobi and Jelle J. Goeman and Ramin Monajemi and Hongcang Gu and Hein Putter and Yanju Zhang and Roderick C. Slieker and Arthur P. Stok and Peter E. Thijssen and Fabian Mueller and Erik W. van Zwet and Christoph Bock and Alexander Meissner and L. H. Lumey and P. Eline Slagboom and Bastiaan T Heijmans},
  booktitle={Nature communications},
  year={2014}
}
Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the characteristics of prenatal malnutrition-associated differentially methylated regions (P-DMRs) is lacking in humans. Here we report on a genome-scale analysis of differential DNA methylation in whole blood after periconceptional exposure to famine during the Dutch Hunger Winter. We show that P-DMRs preferentially occur at regulatory regions, are… CONTINUE READING

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