DNA methylation signatures in development and aging of the human prefrontal cortex.

@article{Numata2012DNAMS,
  title={DNA methylation signatures in development and aging of the human prefrontal cortex.},
  author={Shusuke Numata and Tianzhang Ye and Thomas Michael Hyde and Xavier Guitart-Navarro and Ran Tao and Michael Wininger and Carlo Colantuoni and Daniel R. Weinberger and Joel Edward Kleinman and Barbara K. Lipska},
  journal={American journal of human genetics},
  year={2012},
  volume={90 2},
  pages={260-72}
}
The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain regions to mature. To investigate the role of epigenetics in the development of PFC, we examined DNA methylation in ∼14,500 genes at ∼27,000 CpG loci focused on 5' promoter regions in 108 subjects range in age from fetal to elderly. DNA methylation in the PFC shows unique… CONTINUE READING