DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

  title={DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.},
  author={Maria Eugenia Figueroa and Sanne Lugthart and Yushan Li and CLAUDIA A. J. ERPELINCK-VERSCHUEREN and Xutao Deng and Paul J. Christos and Elizabeth Schifano and James S. Booth and Wim van Putten and Lucy Skrabanek and Fabien Campagne and Madhu Mazumdar and John M. Greally and Peter J. M. Valk and Bob L{\"o}wenberg and Ruud Delwel and Ari Melnick},
  journal={Cancer cell},
  volume={17 1},
We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other… CONTINUE READING
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