DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.

@article{Haldrup2013DNAMS,
  title={DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.},
  author={Christa Haldrup and Kamilla Mundbjerg and Else Marie Vestergaard and Philippe Lamy and Peter J. Wild and Wolfgang A. Schulz and Christian Arsov and Tapio Visakorpi and Michael Borre and S\oren H\oyer and Torben Falck Orntoft and Karina Dalsgaard S\orensen},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2013},
  volume={31 26},
  pages={3250-8}
}
PURPOSE Diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, causing overtreatment of indolent PC and risk of delayed treatment of aggressive PC. Here, we identify six novel candidate DNA methylation markers for PC with promising diagnostic and prognostic potential. METHODS Microarray-based screening and bisulfite sequencing of 20 nonmalignant and 29 PC tissue specimens were used to identify new candidate DNA hypermethylation markers for PC. Diagnostic and prognostic… CONTINUE READING
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