DNA methylation reprogramming in the germ line.

  title={DNA methylation reprogramming in the germ line.},
  author={Diane J. Lees-Murdock and Colum P Walsh},
  volume={3 1},
In mammals, methylation occurs almost exclusively on the CpG dinucleotide in DNA and shows no preference for sequence context surrounding this target. CpGs are found on many different sequence classes and methylation of this dinucleotide is associated with repression of transcription. Reprogramming methylation in the primordial germ cells establishes monoallelic expression of imprinted genes which exhibit monoallelic expression throughout the lifetime of an organism, maintains retrotransposons… CONTINUE READING


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