DNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival.

@article{Mankov2014DNAMP,
  title={DNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival.},
  author={Veronika Man{\vc}{\'i}kov{\'a} and Raquel Buj and Esmeralda Castelblanco and Luc{\'i}a Inglada-P{\'e}rez and Anna Christina Diez and Aguirre A de Cubas and Mar{\'i}a Curr{\'a}s-Freixes and Francisco Xavier Maravall and D{\'i}dac Mauricio and Xavier Mat{\'i}as-Guiu and Manuel Luis Puig-Domingo and Ismael Capel and Maria Rosa Bella and Enrique Lerma and Eva Castella and Jordi Llu{\'i}s Reverter and Miguel {\'A}ngel Peinado and Mireia Jord{\`a} and Mercedes Robledo},
  journal={International journal of cancer},
  year={2014},
  volume={135 3},
  pages={598-610}
}
Thyroid cancer is a heterogeneous disease with several subtypes characterized by cytological, histological and genetic alterations, but the involvement of epigenetics is not well understood. Here, we investigated the role of aberrant DNA methylation in the development of well-differentiated thyroid tumors. We performed genome-wide DNA methylation profiling in the largest well-differentiated thyroid tumor series reported to date, comprising 83 primary tumors as well as 8 samples of adjacent… CONTINUE READING
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CpG island methylator phenotype underlies C an ce r G en et ic s

  • DJ Weisenberger, KD Siegmund, M Campan
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  • 2014

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