DNA methylation profiling of the vascular tissues in the setting of atherosclerosis

@article{Nazarenko2013DNAMP,
  title={DNA methylation profiling of the vascular tissues in the setting of atherosclerosis},
  author={Maria S. Nazarenko and Anton V. Markov and I. N. Lebedev and Alexei Sleptsov and Aleksei V. Frolov and O L Barbarash and Leonid S. Barbarash and V. P. Puzyrev},
  journal={Molecular Biology},
  year={2013},
  volume={47},
  pages={352-357}
}
Currently, the question of epigenetic mechanisms of gene regulation in the context of cardiovascular diseases is of considerable interest. Here, DNA methylation profiles of vascular tissues of atherosclerotic patients have been analyzed for the first time using the Infinium Human Methylation27 BeadChip microarray (Illumina, United States). As the result, within 286 genes, 314 CpG sites that varied significantly in the level of DNA methylation between the tissue samples of carotid (in the area… CONTINUE READING