DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies

@article{Schwalbe2012DNAMP,
  title={DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies},
  author={Edward C. Schwalbe and Daniel Williamson and Janet C. Lindsey and Dolores Hamilton and Sarra L. Ryan and Hisham Megahed and Mikl{\'o}s Garami and P{\'e}ter Hauser and Bożena Dembowska-Bagińska and Danuta Perek and Paul A. Northcott and Michael D. Taylor and Roger E. Taylor and D W Ellison and Simon Bailey and Steven C. Clifford},
  journal={Acta Neuropathologica},
  year={2012},
  volume={125},
  pages={359-371}
}
Molecular subclassification is rapidly informing the clinical management of medulloblastoma. However, the disease remains associated with poor outcomes and therapy-associated late effects, and the majority of patients are not characterized by a validated prognostic biomarker. Here, we investigated the potential of epigenetic DNA methylation for disease subclassification, particularly in formalin-fixed biopsies, and to identify biomarkers for improved therapeutic individualization. Tumor DNA… CONTINUE READING
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