DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis.

@article{Gustafson2004DNAMP,
  title={DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis.},
  author={Karen S Gustafson and Emma Elizabeth Furth and Daniel F. Heitjan and Zoya B Fansler and Douglas P Clark},
  journal={Cancer},
  year={2004},
  volume={102 4},
  pages={259-68}
}
BACKGROUND Cervical carcinoma is a common malignancy among women worldwide, and its pathogenesis is related causally to human papillomavirus infection. The progression from precursor squamous intraepithelial lesions to cervical carcinoma requires additional genetic and epigenetic alterations that have not been characterized fully. The authors examined aberrant promoter methylation of multiple tumor suppressor genes in precursor squamous intraepithelial lesions. METHODS A multiplex, nested… CONTINUE READING
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