DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

@inproceedings{Volkmar2012DNAMP,
  title={DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients},
  author={Michael Volkmar and Sarah Dedeurwaerder and Daniel A Cunha and Matladi N. Ndlovu and Matthieu Defrance and Rachel Deplus and Emilie Calonne and Ute Volkmar and Mariana Igoillo-Esteve and Najib Naamane and Silvia Del Guerra and Matilde Masini and Marco Bugliani and Piero Marchetti and Miriam Cnop and Decio L. Eizirik and François Fuks},
  booktitle={The EMBO journal},
  year={2012}
}
In addition to genetic predisposition, environmental and lifestyle factors contribute to the pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for translating environmental exposures into pathological mechanisms. In this study, we performed the first comprehensive DNA methylation profiling in pancreatic islets from T2D and non-diabetic donors. We uncovered 276 CpG loci affiliated to promoters of 254 genes displaying significant differential DNA methylation in… CONTINUE READING
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